Dr. Gautam Allahbadia's video: What is the role of AMH in my IVF workup

AMH, or anti-mullerian hormone is a substance produced by granulosa cells in ovarian follicles. It is first made in primary follicles that advance from the primordial follicle stage. At these stages follicles are microscopic and can not be seen by ultrasound. AMH production is highest in preantral and small antral stages (less than 4mm diameter) of development. Production decreases and then stops as follicles grow. There is almost no AMH made in follicles over 8mm. Therefore, the levels are fairly constant and the AMH test can be done on any day of a woman’s cycle. AMH levels accurately reflect the ovarian follicular reserve and could, therefore, be considered as an extremely sensitive marker of ovarian aging. Additionally, AMH could be a surrogate diagnostic marker of polycystic ovary syndrome in cases in which ultrasonographic examination is not possible. With increasing female age, the size of their pool of remaining microscopic follicles decreases. Likewise, their blood AMH levels and the number of ovarian antral follicles visible on ultrasound also decreases. Women with many small follicles, such as those with polycystic ovaries have high AMH hormone values and women that have few remaining follicles and those that are close to menopause have low anti-mullerian hormone levels. Women with higher AMH values will tend to have better response to ovarian stimulation for IVF and have more eggs retrieved. In general, having more eggs with IVF gives a higher success rate. AMH levels less than 1.5 ng/mL in women less than 35 years appear to predict lower clinical pregnancy rates in women undergoing in-vitro fertilization, even in the setting of normal day 2 ovarian reserve testing. Consideration should be given to transferring more embryos in women less than 35 years with AMH values less than 1.5 ng/ml. AMH may be used as a sole measure of ovarian reserve in young women if significantly low. Get the best solution to all your Fertility problems with Dr. Gautam Allahbadia. . . Book your appointments now! 📧 ivfwaladoc@gmail.com 🌐 www.gautamallahbadia.com . . "