G. Stolyarov II's video: U S Transhumanist Party Enlightenment Salon with Aubrey de Grey on Robust Mouse Rejuvenation

On February 19, 2023, the U.S. Transhumanist Party invited Dr. Aubrey de Grey to discuss the flagship project of his new Longevity Escape Velocity Foundation (LEV Foundation) – the Robust Mouse Rejuvenation Study 1, the first of multiple planned ambitious studies on mouse longevity using a combination of interventions. The Robust Mouse Rejuvenation Study 1 began shortly after the Salon, and this was an opportune occasion for Dr. de Grey to discuss the aims and design of the study and to field audience questions regarding it. Dr. Aubrey de Grey is President and Chief Science Officer of the LEV Foundation, where U.S. Transhumanist Party Chairman Gennady Stolyarov II serves on the Board of Directors. Find out about the LEV Foundation here: https://www.levf.org/ Read the Robust Mouse Rejuvenation Study 1 description on the LEV Foundation website: https://www.levf.org/projects/robust-mouse-rejuvenation-study-1 Timestamps 3:49 - Aubrey de Grey’s introduction (Longevity Escape Velocity (LEV), Hallmarks of Aging, Robust Mouse Rejuvenation (RMR), LEV Foundation, middle-aged mice, philanthropy, study design, start date, mouse strain, location, effect size, why LEV achievement is more likely for longer lived species, health measures, 2 controls, survival curve timepoints, the 4 interventions, therapy design, inspirations and gratitude, mouse surgery 50:33 - Jose Cordeiro asking about RMR timeline, and about cryonics (answer also covered the publicity plan) 55:21 - Audience questions on grip strength, AI use, and Harold Katcher 1:02:57 - Bill Andrews lauding LEV Foundation’s work 1:04:39 - David Wood asking what animal will be next, and who might do it, and a follow-up about mouse telomerase reverse transcriptase (mTERT) that Bill Andrews also weighed in on 1:11:42 - Audience questions on telomere length in lab mice, and availability of RMR for humans 1:16:19 - Dan Elton asking about organ cryopreservation, with David Wood following up about funding for its research 1:20:46 - Edward Hudgins expressing excitement for how LEV Foundation’s work will help the public see the possibility of doing something about aging 1:23:23 - Arin Vahanian asking about ways other than funding that people could help LEV Foundation and other such organizations 1:28:04 - Art Ramon Garcia asking about mitochondrial transplants 1:31:45 - John Kerecz expressing enthusiasm for the prospect of what works in mice working in humans 1:32:43 - Audience (and panel) questions on mouse therapy translating to humans, measures within the RMR study, how LEV Foundation’s work might change discourse on human longevity initiatives, which RMR treatment shows the most promise, how to get longevity-aligned research organizations to help in the type of work pursued by LEV Foundation, and if RMR treatments might reduce damage to the extracellular matrix 1:46:29 - Dan Elton asking about Rejuvenome, another mouse longevity project 1:51:14 - Aubrey de Grey’s closing remarks on his outlook for LEV Foundation, and on what success would look like to him The USTP held two previous Virtual Enlightenment Salons with Aubrey de Grey. Watch the Virtual Enlightenment Salon of February 21, 2021, where Dr. de Grey was the guest of honor: https://www.youtube.com/watch?v=ohet4kAfskM Watch the Virtual Enlightenment Salon of September 18, 2022, aired during Day 1 of the Longevity Summit Dublin, where we spoke with Dr. de Grey for the majority of the broadcast: https://www.youtube.com/watch?v=pQfIt2IUlVc Join the U.S. Transhumanist Party for free, no matter where you reside: https://transhumanist-party.org/membership