Haircafe's video: Why Bryan Johnson should promote finasteride the ultimate anti-aging and longevity drug

Linked videos: DHT trash hormone: https://youtu.be/PS-kynh8pLE https://youtu.be/G6XrzHQk_DI https://youtu.be/Tzu_yWBR_rU https://youtu.be/wRXZY-wY8b0 https://youtu.be/eSVhcp0jmKE https://youtu.be/H_07OCa_1h4 https://youtu.be/nMWvPe5PQCg https://youtu.be/UxcqZO3F6kA https://youtu.be/MdmXIeH39FU https://youtu.be/wRXZY-wY8b0 Finasteride effects on neurosteroids, brain: https://youtu.be/MdmXIeH39FU https://youtu.be/-AN7fDyET-g https://youtu.be/1p5RD1Yd6jE https://youtu.be/sHDdNR3MUeI https://youtu.be/kkvxuqqRBOw https://youtu.be/2hYqoY7kzi0 https://youtu.be/EkS6_wub7W8 https://youtu.be/EgYczERIkBg Sources: 1. Haider AW, Larson MG, Benjamin EJ, Levy D. Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. Journal of the American College of Cardiology. 1998;32(5):1454-1459. doi:10.1016/S0735-1097(98)00407-0 2. Thompson IM, Goodman PJ, Tangen CM, et al. The Influence of Finasteride on the Development of Prostate Cancer. New England Journal of Medicine. 2003;349(3):215-224. doi:10.1056/NEJMoa030660 3. Gilliver SC, Ashworth JJ, Mills SJ, Hardman MJ, Ashcroft GS. Androgens modulate the inflammatory response during acute wound healing. J Cell Sci. 2006;119(Pt 4):722-732. doi:10.1242/jcs.02786 4. Gilliver SC, Ruckshanthi JPD, Atkinson SJ, Ashcroft GS. Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing. Lab Invest. 2007;87(9):871-881. doi:10.1038/labinvest.3700627 5. Anitha B, Inamadar AC, Ragunatha S. Finasteride-Its Impact on Sexual Function and Prostate Cancer. J Cutan Aesthet Surg. 2009;2(1):12-16. doi:10.4103/0974-2077.53093 6. Cunningham RL, Giuffrida A, Roberts JL. Androgens Induce Dopaminergic Neurotoxicity via Caspase-3-Dependent Activation of Protein Kinase Cδ. Endocrinology. 2009;150(12):5539-5548. doi:10.1210/en.2009-0640 7. Gilliver S, Ruckshanthi J, Hardman M, Zeef L, Ashcroft G. 5α-Dihydrotestosterone (DHT) retards wound closure by inhibiting re-epithelialization. The Journal of Pathology. 2009;217(1):73-82. doi:10.1002/path.2444 8. Andriole GL, Bostwick DG, Brawley OW, et al. Effect of Dutasteride on the Risk of Prostate Cancer. New England Journal of Medicine. 2010;362(13):1192-1202. doi:10.1056/NEJMoa0908127 9. Gold EB. The Timing of the Age at Which Natural Menopause Occurs. Obstetrics and Gynecology Clinics of North America. 2011;38(3):425. doi:10.1016/j.ogc.2011.05.002 10. Hoefflin JD. Treatment of Aging Skin with Topical Ethocyn®: Plastic and Reconstructive Surgery. 2011;128:110. doi:10.1097/01.prs.0000406341.77839.a2 11. Bytyçi I, Bajraktari G. Mortality in heart failure patients. Anatol J Cardiol. 2015;15(1):63-68. doi:10.5152/akd.2014.5731 12. Litim N, Bourque M, Al Sweidi S, Morissette M, Di Paolo T. The 5α-reductase inhibitor Dutasteride but not Finasteride protects dopamine neurons in the MPTP mouse model of Parkinson’s disease. Neuropharmacology. 2015;97:86-94. doi:10.1016/j.neuropharm.2015.05.015 13. Frau R, Savoia P, Fanni S, et al. The 5-alpha reductase inhibitor finasteride reduces dyskinesia in a rat model of Parkinson’s disease. Experimental Neurology. 2017;291:1-7. doi:10.1016/j.expneurol.2017.01.012 14. Kim HI, Lim H, Moon A. Sex Differences in Cancer: Epidemiology, Genetics and Therapy. Biomol Ther (Seoul). 2018;26(4):335-342. doi:10.4062/biomolther.2018.103 15. Seo JO, Yumnam S, Jeong KW, Kim SY. Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells. Arch Pharm Res. 2018;41(3):324-332. doi:10.1007/s12272-018-1002-x 16. Goodman PJ, Tangen CM, Darke AK, et al. Long-Term Effects of Finasteride on Prostate Cancer Mortality. New England Journal of Medicine. 2019;380(4):393-394. doi:10.1056/NEJMc1809961 17. Kattih B, Elling LS, Weiss C, et al. Anti-androgenic therapy with finasteride in patients with chronic heart failure - a retrospective propensity score based analysis. Sci Rep. 2019;9(1):10139. doi:10.1038/s41598-019-46640-8 18. Papademetriou V, Stavropoulos K, Kokkinos P, et al. Left Ventricular Hypertrophy and Mortality Risk in Male Veteran Patients at High Cardiovascular Risk. The American Journal of Cardiology. 2020;125(6):887-893. doi:10.1016/j.amjcard.2019.12.029 19. Kim HJ, Kim TJ, Kim YG, et al. Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells. Pharmaceutics. 2021;13(9):1410. doi:10.3390/pharmaceutics13091410 20. Zhao E, Crimmins EM. Mortality and morbidity in ageing men: Biology, Lifestyle and Environment. Rev Endocr Metab Disord. 2022;23(6):1285-1304. doi:10.1007/s11154-022-09737-6 21. Apaijai N, Pintana H, Saengmearnuparp T, Chattipakorn SC, Chattipakorn N. Finasteride effectively attenuates the impairments of left ventricular function and cardiac sympathovagal balance in both aging and obese male rats via reducing systemic oxidative stress. European Heart Journal. 2023;44(Supplement_2):ehad655.2874. doi:10.1093/eurheartj/ehad655.2874