Haircafe's video: The Broscience of Hair Loss DHT and Bludflow with Andrew Huberman

00:00 Introduction 05:02 Bludflow 11:12 Minoxidil 12:40 Minoxidil and prolactin 14:19 Caffeine 16:00 Botox 19:23 Microneedling 21:10 Saw palmetto 22:33 DHT 23:50 Post-finasteride syndrome 25:14 Conclusion Videos mentioned: PFS videos: https://youtu.be/tx8c3BvfuWw https://youtu.be/dXwO0E2A7LI https://youtu.be/YM4DJbK9HQY https://youtu.be/kHhxHtKGmBo https://youtu.be/PVLJMwUFDvI https://youtu.be/ykk3UVyeCiA https://youtu.be/iDeDcBg4esk Bludflow, scalp massage: https://youtu.be/icSupaq9hBA https://youtu.be/P_UngSNEr98 https://youtu.be/IfLvjEjdcnE What I've Learned: https://youtu.be/X5tVmX8mIF4 Tretinoin: https://youtu.be/hj4WU3hmc9w Caffeine: https://youtu.be/la8ryTZFUQI New microneedling study: https://youtu.be/aNqMq3l0SOM Reishi mushrooms: https://youtu.be/i1APPNP0c9g DHT trash hormone series: https://youtu.be/Tzu_yWBR_rU https://youtu.be/wRXZY-wY8b0 https://youtu.be/eSVhcp0jmKE https://youtu.be/H_07OCa_1h4 https://youtu.be/nMWvPe5PQCg https://youtu.be/UxcqZO3F6kA https://youtu.be/MdmXIeH39FU https://youtu.be/wRXZY-wY8b0 Neurosteroids: https://youtu.be/sHDdNR3MUeI https://youtu.be/kkvxuqqRBOw https://youtu.be/2hYqoY7kzi0 https://youtu.be/EkS6_wub7W8 https://youtu.be/EgYczERIkBg Sources: 1. Minoxidil: Package Insert. Drugs.com. Accessed April 17, 2023. https://www.drugs.com/pro/minoxidil.html 2. Osborn D. INHERITANCE OF BALDNESS. Journal of Heredity. 1916;7(8):347-355. doi:10.1093/oxfordjournals.jhered.a110746 3. Goldman BE, Fisher DM, Ringler SL. Transcutaneous PO2 of the scalp in male pattern baldness: a new piece to the puzzle. Plast Reconstr Surg. 1996;97(6):1109-1116; discussion 1117. doi:10.1097/00006534-199605000-00003 4. Shoemaker JK, Tiidus PM, Mader R. Failure of manual massage to alter limb blood flow: measures by Doppler ultrasound. Med Sci Sports Exerc. 1997;29(5):610-614. doi:10.1097/00005768-199705000-00004 5. van Broekhoven F, Verkes RJ. Neurosteroids in depression: a review. Psychopharmacology. 2003;165(2):97-110. doi:10.1007/s00213-002-1257-1 6. Messenger AG, Rundegren J. Minoxidil: mechanisms of action on hair growth. Br J Dermatol. 2004;150(2):186-194. doi:10.1111/j.1365-2133.2004.05785.x 7. Freund BJ, Schwartz M. Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study. Plastic and Reconstructive Surgery. 2010;126(5):246e. doi:10.1097/PRS.0b013e3181ef816d 8. Fischer TW, Herczeg‐Lisztes E, Funk W, Zillikens D, Bíró T, Paus R. Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles in vitro. Br J Dermatol. 2014;171(5):1031-1043. doi:10.1111/bjd.13114 9. Basaria S, Jasuja R, Huang G, et al. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss. The Journal of Clinical Endocrinology & Metabolism. 2016;101(12):4669-4680. doi:10.1210/jc.2016-2726 10. Di Pietro A, Piraccini BM. Frontal Alopecia after Repeated Botulinum Toxin Type A Injections for Forehead Wrinkles: An Underestimated Entity? Skin Appendage Disord. 2016;2(1-2):67-69. doi:10.1159/000448380 11. Dhurat R, Chitallia J, May TW, et al. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia. Skin Pharmacol Physiol. 2018;30(6):298-305. doi:10.1159/000481141 12. Kim S, Kim SN, Jeong G, et al. Efficacy of Caffeine in Promoting Hair Growth by Enhancing Intracellular Activity of Hair Follicles. Korea Journal of Cosmetic Science. 2019;1(1):11-18. doi:10.15230/SCSK.2019.1.1.11 13. Shon U, Kim MH, Lee DY, Kim SH, Park BC. The effect of intradermal botulinum toxin on androgenetic alopecia and its possible mechanism. J Am Acad Dermatol. 2020;83(6):1838-1839. doi:10.1016/j.jaad.2020.04.082 14. Völker JM, Koch N, Becker M, Klenk A. Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review. SPP. 2020;33(3):153-169. doi:10.1159/000508228 15. Zhou Y, Chen C, Qu Q, et al. The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta-analysis. Dermatologic Therapy. 2020;33(4):e13741. doi:10.1111/dth.13741 16. Ye J, Tang X, Long Y, Chu Z, Zhou Q, Lin B. The effect of hypoxia on the proliferation capacity of dermal papilla cell by regulating lactate dehydrogenase. Journal of Cosmetic Dermatology. 2021;20(2):684-690. doi:10.1111/jocd.13578 17. Kinter KJ, Anekar AA. Biochemistry, Dihydrotestosterone. In: StatPearls. StatPearls Publishing; 2022. Accessed December 28, 2022. http://www.ncbi.nlm.nih.gov/books/NBK557634/