MedLecturesMadeEasy's video: Hypothyroidism Hyperthyroidism and Thyroiditis

This is a brief video on assorted thyroid diseases, including those that cause hypothyroidism, hyperthyroidism, and inflammation of the thyroid. I created this presentation with Google Slides. Image were created or taken from Wikimedia Commons I created this video with the YouTube Video Editor. ADDITIONAL TAGS: fatigue, cold intolerance, impaired memory/concentration, constipation, weight gain, poor appetite, SoB, hoarseness, dry skin, myxedema, periorbital swelling, carpal tunnel glycosaminoglycans (thyroid hormones mediate GAG reuptake) Can progress to myxedema coma Bradycardia, hypotension, hypothermia administer hormone Hypothyroidism Congenital hypothyroidism Other hypothyroidism Hashimoto thyroiditis Subacute thyroiditis Fibrous thyroiditis Hyperthyroidism Graves disease Toxic multinodular goiter Jod-Basedow phenomenon Congenital hypothyroidism cretinism thyroid peroxidase (causing thyroid dysgenesis) Thyroid agenesis Maternal hypothyroidism Iodine deficiency : poor brain development; pale; protruding tongue; protruding umbilicus; pot-bellied; puffy face Hypopituitarism of any cause (secondary hypothyroidism) : lithium, amiodarone, Amiodarone molecule has iodines; excess iodine physiologically decreases hormone production Wolff-Chaikoff downregulates thyroid peroxidase Iodine deficiency Commiodine-deficient parts of world, very rare United States AKA autoimmune primary hypothyroidism or chronic lymphocytic thyroiditis Most commcause the US Autoimmune High titer of antithyroid Ab follicular rupture Gross: firm, nontender, enlarged Hurthle cells (epithelial cells pink changes to epithelium → oncocytic metaplasia); lymphoid aggregates (mix of large and small cells) germinal centers (so think chronic inflammation) Typically permanent Associated HLA-DR5 Increased risk of non-Hodgklymphoma, often arising from B-cells marginal zone AKA granulomatous thyroiditis or de Quervain's hyperthyroidism, often euthyroid , follows viral infection Clinical: Tender thyroid, painful the jaw, ESR Gross: asymmetrically enlarged, fibrotic, very tender exam granulomas; follicles replaced histiocytes and giant cells; fibrosis Treat NSAIDs, prednisone dense fibrosis hard as rock stone IgG4-related disease (IgG4-RD), systemic disease, associated infiltrati IgG4 secreting plasma nervousness, irritability, perspiration, palpitations, hand tremors, anxiety, difficulty sleeping, increased appetite, weight loss, hyperdefecation, malabsorption, thinning skin, brittle hair, upper/lower extremity muscular weakness, stare or lid retractieyes,