Solution- Pharmacy's video: Topic 77 Pharmacophore Model Medicinal Chemistry 03 B Pharmacy 6th Semester QSAR

Download the "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Tests and other GPAT Materials - https://play.google.com/store/apps/details?id=co.bolton.nqilv Contents for Unit 05 of Medicinal Chemistry 03 Introduction to Drug Design Various approaches are used in drug design. Physicochemical parameters used in quantitative structure-activity relationships (QSAR) such as partition coefficient, Hammet’s electronic parameter, Taft's steric parameter and Hansch analysis. Pharmacophore modelling and docking techniques. Combinatorial Chemistry: Concept and Applications of combinatorial chemistry: solid phase and solution phase synthesis. Pharmacophore modeling A pharmacophore is a molecular frame that describes the vital features responsible for the biological activity of a molecule. Pharmacophore modeling is the state-of-the-art technology used to identify and extract the possible interactions between a ligand–receptor complex. The identified interactions consist of standard steric and electronic features, which are essential to trigger a biological responsePharmacophore modeling is widely employed in virtual screenings to identify the molecules that trigger the desired biological activity. Pharmacophore models are also used as filters to identify molecules that meet the pharmacophore requirements prior to, during, and after docking. Pharmacophore models are generated to increase the understanding about the ligand–protein interactions. They can be employed in identifying new molecules that satisfy the pharmacophore requirements and thus are expected to be active. 1. Ligand-based pharmacophore modeling: Pharmacophore models can be built by using the structural information about the active ligands that bind to the target if the target structure is not available. This is known as the ligand-based pharmacophore modeling approach. 3D Ligand-Based Pharmacophore Modeling. 3D ligand-based pharmacophore modeling consists of several stages: (1) training and test set preparation; (2) model development and selection; and (3) external validation of selected models 2. Structure-based pharmacophore modelingIn conditions where the structure of the target is available, pharmacophore models can be built by using the structural properties of the target. This is known as structure-based pharmacophore modeling An example of a pharmacophore model of the benzodiazepine binding site on the GABAA receptor. Pharmacophore is essential to understand the interaction between the receptor and ligand. It is an important feature to design new drugs for the treatment of the intended disease. Pharmacophore is defined as the essential geometric arrangement of atoms or functional groups necessary to produce a given biological response. Get in touch with the solution by just clicking the following links- Facebook Group- https://www.facebook.com/groups/solutionpharamcy Mobile App - https://play.google.com/store/apps/details?id=co.bolton.nqilv New Channel (Pharmacy Dictionary) https://www.youtube.com/channel/UCt6OXVV_2oxf5DD0Mad6e9A E-Mail for official and other work - solutionpharmacy@gmail.com