SpecBN's video: Incidence rates of aggressive subtypes of uterine cancer rising

Subscribe Please! like our Facebook Page: https://www.facebook.com/SpecBN/ Visite our website: http://specbn.com Follow our Twitter: https://www.twitter.com/specbn News: https://bitlylink.com/fVkDD New findings from a study by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, show that U.S. incidence rates for aggressive subtypes of uterine cancer rose rapidly among women ages 30 to 79 from 2000 to 2015. The findings also reveal racial disparities, including higher incidence of these aggressive subtypes and poorer survival—irrespective of subtype and cancer stage—among non-Hispanic black women than among women in other racial/ethnic groups. The study, published May 22, 2019 in the Journal of Clinical Oncology, used population data from NCI’s Surveillance, Epidemiology, and End Results (SEER) database to evaluate trends in uterine cancer incidence rates for women overall and by race and ethnicity, geographic region, and histologic subtype (subtypes differentiated by how tumor tissue appears under a microscope). The authors corrected for hysterectomy prevalence, using data from the Behavioral Risk Factor Surveillance System, in estimating incidence rates of uterine cancer because women who have had a hysterectomy are no longer at risk for developing the disease. Many past studies of uterine cancer incidence did not include such a correction. “Incidence rates of uterine cancer have been rising, and there have been previous reports of racial differences in incidence and survival rates, with disparities observed for non-Hispanic black women,” said Megan Clarke, Ph.D., lead author of the study and a postdoctoral fellow in NCI’s Division of Cancer Epidemiology and Genetics. “But few recent studies have corrected for hysterectomy, which can vary by race and ethnicity and by region. Correcting for hysterectomy prevalence gives us a more accurate picture of trends in overall incidence, as well as rates by race and ethnicity.” The study found that, among all women, hysterectomy-corrected uterine cancer incidence rates overall increased by about 1% per year from 2003 to 2015. Incidence rates increased more rapidly among women of other racial/ethnic groups than among white women. Uterine cancer incidence rates among black women surpassed those among white women in 2007 and were consistently higher from 2011 through 2015. The researchers also looked separately at data on endometrioid and nonendometrioid subtypes of uterine cancer. Compared with nonendometrioid subtypes, endometrioid subtypes are more common, generally have better prognoses and survival rates, and have a stronger association with hormonal risk factors and obesity. A novel approach to account for missing histology information was used to improve subtype-specific incidence estimates. Incidence rates of endometrioid subtypes were stable in non-Hispanic white women over the study period and increased in women of other racial/ethnic groups. By contrast, incidence rates of aggressive, nonendometrioid subtypes have been increasing dramatically over time in all racial/ethnic groups (overall increase of 2.9% per year from 2000 to 2015). The researchers also observed much higher rates of the aggressive, nonendometrioid subtypes in black women (25.9 per 100,000 women over the study period) than in white women (11.4), Hispanic women (10.1), and Asian/Pacific Islander women (7.5). Reference: https://bitlylink.com/cej4I