ilovepathology's video: PATHOLOGIC CALCIFICATION: Dystrophic Metastatic Calcification

A series of video tutorials discussing the pathology of cell injury and adaptations. In this tutorial , i have discussed Pathologic Calcification. ****Follow me***** http://ilovepathology.com/ Twitter : https://twitter.com/VijayPatho https://twitter.com/ilovepathology2 Facebook: https://www.facebook.com/ilovepathology/ PATHOLOGIC CALCIFICATION Abnormal tissue deposition of calcium salts, together with smaller amounts of iron, magnesium, and other mineral salts DYSTROPHIC CALCIFICATION Occurs locally in dead and degenerated tissues Normal levels of serum calcium Absence of derangements in calcium metabolism METASTATIC CALCIFICATION Deposition in normal tissues Increased levels of serum calcium Disturbance in calcium metabolism (in hyperparathyroidism, bone damage or diseases etc METASTATIC CALCIFICATION 1. 4 Primary causes 1. Elevated PTH causing bone resorption 1. Primary hyperparathyroidism : adenomas 2. Secondary hyperparathyroidism : paraneoplastic syndromes 2. Destruction of bone, in tumors like myeloma, leukemia and other tumors 3. Vitamin D related disorders like intoxication – increased absorption of calcium 4. Renal failure (phosphate retention so increased PTH) 2. Occurs throughout the body but favors tissues that excrete acid - ( internal environment is alkaline) favoring calcium deposition. 3. Gastric mucosa( around fundic glands), lungs ( alveolar wall), kidneys( tubules) Morphology Macroscopy: Can vary in size, white granules which may be gritty Microscopy: Basophilic, amorphous or granular appearance/ in clumps. Intracellular, extracellular or both in H & E stained sections • Psammoma bodies: concentric laminations of calcium deposition. -~-~~-~~~-~~-~- Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?" https://www.youtube.com/watch?v=LXaO59IqQm8 -~-~~-~~~-~~-~-